Tohoku University Technology: Diagnostic Method for Primary Aldosteronism: T12-182
Adrenal venous blood samples accurately distinguish between tumor and non-tumor using HSD3B2 antibodies.
Primary aldosteronism is a condition characterized by the autonomous overproduction of steroids from the adrenal glands, and salt-sensitive primary aldosteronism is a disease that causes salt-sensitive hypertension due to this autonomous steroid overproduction. There are two pathological conditions: tumor-related (APA) and non-tumor-related (IHA), and since the treatment methods differ, differential diagnosis is important (APA requires adrenalectomy, while IHA is treated with medication). Until now, no markers have been found to distinguish between APA and IHA, making differentiation difficult, as morphological differences were used as criteria during definitive diagnosis based on pathological specimens. The inventors elucidated the 3βHSD-related steroid metabolic pathways in normal adrenal glands, IHA, and APA, and developed an evaluation method using the ratios as indicators in adrenal venous blood samples. Additionally, they established a monoclonal antibody specific to HSD3B2, which is abundant in APA, and achieved the differentiation of the pathological conditions of APA and IHA through immunostaining by using it in combination with HSD3B1 antibody.
- Company：Tohoku Techno Arch Co., Ltd.
- Price：Other
